OLIGONUCLEOTID TABLETS: Process to formulate oligonucleotids into tablets for an oral administration

APPLICATIONS

  • New galenic formulation for therapeutic approach based on oligonucleotids
  • Tablets suitable for siRNA, shRNA, miRNA, mRNA and RNAi
  • Oral administration of biological active molecules

INVENTORS

Pierre TCHORELOFF
Virginie BUSIGNIES-GODDIN
Institut de Mécanique et d’Ingénierie de Bordeaux (I2M, UMR 5295)
Team: Galenics – Mechanics of Compacted Pharmaceutical Powders
Virginie ESCRIOU
Pascal BIGEY
Christine CHARRUEAU
Laboratory of “Chemical and Biological Technologies for Health” (Paris, UTCBS, UMR 8258, U 1022)

CONTACT

Nom : Lucile Tran,
Titre : Healthcare Project Manager,
Mail : l.tran@ast-innovations.com

DESCRIPTION

  • Patented process to compress into tablets the oligonucleotids while maintaining their therapeutic activity
  • Compatible with large panel of encapsulated vectors
  • Possibility to combine the approach with the well known process to control the delivery
  • Combination of multiple therapeutic oligonucleotids in a single tablet

BENEFITS

  • Opens new perspectives for simple use of therapeutic oligonucleotids
  • Obtention of sterilized, stable, easy to store tablets
  • High patient compliance expected
By | 2018-01-22T18:00:41+00:00 mai 22nd, 2017|