Lymphoma Mouse Model: a useful model for rapid biological and therapeutic evaluation

DESCRIPTION

  • Original method of intrahepatic injection of CTCL into adult immunodeficient mice
  • Engraftment validated with aggressive (My-La, HUT78, HH, MAC2A, MAC2B) and indolent (FE-PD, MAC1) CTCL cell lines, DLBCL cell line (HLY1) and patient-derived CTCL xenograft
  • Migration and cell spreading assessment in blood, kidneys, lungs, spleen …
  • Model validation with methotrexate as positive drug control treatment

INVENTORS

Jean-Philippe MERLIO
Edith CHEVRET
Sandrine POGLIO
Bordeaux Research in Translational Oncology (BaRITOn, U 1053) 

CONTACT

Nom : Lucile Tran,
Titre : Chef de Projet Santé,
Mail : l.tran@ast-innovations.com

APPLICATIONS

  • A preclinical model to assess single or multi-agent therapies for lymphomas (cutaneous T-cell lymphoma cell lines, B-cell lymphoma cell lines and PDX model)
  • A robust, reproducible and quick (15 days) model for in vivo drug testing
  • Preclinical evaluation of cutaneous lymphoma proliferation, tumor growth and migration

BENEFITS

  • Preclinical studies in appropriate and relevant model of cutaneous and other lymphomas
  • In vivo screening of therapeutic molecules in different compartments
  • Compatible with imaging or monitoring methods of cutaneous lymphoma cells and other lymphomas

IP

This technology is protected by a patent application

By | 2017-04-21T12:25:54+00:00 avril 21st, 2017|