The Premamask device characteristics are strong assets in comparison with current masks: No skin nor airways damages because without using pressure and biocompatible even for premature babies Accurately sized for premature or full term babies Air and humidity tight Sterilisable Very mobile and repositionable – easy mother skin contact
Identification of a core molecule X1 involved in melanocytes detachment responsible for depigmentation in vitiligo and post-inflammatory skin disorders Ex vivo analysis −Higher X1 expression in vitiligo patients’ skin and sera compared to healthy subjects −Vitiligo patients: Positive correlation between X1 level and the body surface area involved POC in vitro: −Inhibitors targeting X1 prevent melanocyte detachment in a 3D-induced depigmentation model
This project aims to develop orthopedic implants based on titanium functionalized with intelligent antibiotic systems. Antibiotic release systems (widely used to prevent infections during orthopedic surgery) are controlled by a change in pH on bone implants typically observed in bacterial infections.
Fully based on 3D approach, the technology implements a four steps method from virtual planning of an orthognathic mandibular osteotomy to the production of a simple and reliable device to conduct surgery, including: Acquisition and surface extraction; Virtual planning; Modelling & printing; OCPD evaluation.
BACTERIOLOGICAL MICRO REACTOR: Bio-reactors made of Silica allowing micro organisms cascade reactions
Little balls made of porous Silica encapsulating micro organisms that can then proliferate easily in all the pores The micro organism proliferation following this new production way is twice more efficient (both in terms of speed of proliferation and of population per volume) than classical sol-gel method Cascade reactions can be implemented and then create more synergies and catalytic effects
Original method of intrahepatic injection of CTCL into adult immunodeficient mice Engraftment validated with aggressive (My-La, HUT78, HH, MAC2A, MAC2B) and indolent (FE-PD, MAC1) CTCL cell lines, DLBCL cell line (HLY1) and patient-derived CTCL xenograft Migration and cell spreading assessment in blood, kidneys, lungs, spleen … Model validation with methotrexate as positive drug control treatment
Identification of 2 circulating inflammatory metabolites triggering AHT High expression of these metabolites in individuals with active clinical and immunological states Metabolites able to induce the main clinical features of AHT in mice On-going biomedical study for monitoring the metabolites in patients with hypertension
Innovative technology based on Surface Plasmon Resonance (SPR) in a capture mode, Access to HLA antibodies’ active concentration and affinity, Active concentration (high capture level) and affinity (low capture level) of several sample/HLA targets can be performed on the same chip.