INDEME: A targeted approach for depigmentation disorders

Identification of a core molecule X1 involved in melanocytes detachment responsible for depigmentation in vitiligo and post-inflammatory skin disorders Ex vivo analysis −Higher X1 expression in vitiligo patients’ skin and sera compared to healthy subjects −Vitiligo patients: Positive correlation between X1 level and the body surface area involved POC in vitro: −Inhibitors targeting X1 prevent melanocyte detachment in a 3D-induced depigmentation model

By | 2018-02-08T17:18:03+00:00 avril 21st, 2017|

Bioactive implants

This project aims to develop orthopedic implants based on titanium functionalized with intelligent antibiotic systems. Antibiotic release systems (widely used to prevent infections during orthopedic surgery) are controlled by a change in pH on bone implants typically observed in bacterial infections.

By | 2018-02-08T17:23:08+00:00 avril 21st, 2017|

3D printed occlusal & condylian guide

Fully based on 3D approach, the technology implements a four steps method from virtual planning of an orthognathic mandibular osteotomy to the production of a simple and reliable device to conduct surgery, including: Acquisition and surface extraction; Virtual planning; Modelling & printing; OCPD evaluation.

By | 2018-02-08T17:24:33+00:00 avril 21st, 2017|

BACTERIOLOGICAL MICRO REACTOR: Bio-reactors made of Silica allowing micro organisms cascade reactions

Little balls made of porous Silica encapsulating micro organisms that can then proliferate easily in all the pores The micro organism proliferation following this new production way is twice more efficient (both in terms of speed of proliferation and of population per volume) than classical sol-gel method Cascade reactions can be implemented and then create more synergies and catalytic effects

By | 2018-02-08T17:26:47+00:00 avril 21st, 2017|

Lymphoma Mouse Model: a useful model for rapid biological and therapeutic evaluation

Original method of intrahepatic injection of CTCL into adult immunodeficient mice Engraftment validated with aggressive (My-La, HUT78, HH, MAC2A, MAC2B) and indolent (FE-PD, MAC1) CTCL cell lines, DLBCL cell line (HLY1) and patient-derived CTCL xenograft Migration and cell spreading assessment in blood, kidneys, lungs, spleen … Model validation with methotrexate as positive drug control treatment

By | 2018-02-08T17:33:05+00:00 avril 21st, 2017|

QUANTI-HLAb: An In Vitro Diagnostic Kit for transplant recipients

Innovative technology based on Surface Plasmon Resonance (SPR) in a capture mode, Access to HLA antibodies’ active concentration and affinity, Active concentration (high capture level) and affinity (low capture level) of several sample/HLA targets can be performed on the same chip.

By | 2018-02-08T17:35:03+00:00 avril 4th, 2017|