Around 30,000 new cases of sarcomas are diagnosed every year in the US and EU Sarcomas are rare cancers for which treatments and prognoses can vary widely The classification and prediction of the metastasis risk is particularly difficult and currently the analysis is based on a histological grade. Such analysis is not very accurate and can often leads to sub-optimal patient management
UNIVERSLIDE: A versatile imaging chamber to observe biological samples in 3D/4D – suitable for all kinds of microscopes
Chamber frame designed to receive a coverslip (optical access from the bottom) Clip-on PDMS gasket to guarantee the system tightness Agarose substrate with an array of little wells Upper lid with second glass coverslip to seal the device and to provide optical access from top No stress nor strain on the sample, to guarantee the sample integrity
The 5 strains followed the same selection procedure : Adhesion test on glass tube: verification of the production of exopolysaccharides confirming that the bacteria can adhere to hard tissues, Hydrophobicity test, Co-aggregation test with bacteria responsible for periodontal disease and halitosis, Test of antibacterial activity against potentially pathogenic strains in the oral cavity, Saliva survival test: resistance and stability of probiotic candidates in the salivary environment. Safety Test: Verification that strains do not produce compounds responsible for bad breath, Immunogenicity test to understand the local immune response.
FibroCOPD: Drug repurposing for the treatment of chronic obstructive pulmonary disease (COPD) APPLICATIONS Treatment acting directly on lung function decline and mortality in [...]
Repurposing molecule improving symptoms associated with obstructive cardiopathies and especially hypertrophic cardiomyopathy: exercise breathlessness exercise chest pain exercise discomfort exercise dizziness Validation with a first serie of human obstructive heart diseases Reduction of symptoms at rest or during effort Immediate decrease of intraventricular obstruction and hyperkinetic state Ongoing phase II clinical study on 40 patients